On dry land, 220s are great otter traps. In the water, 280 is usually a better choice in my opinion, although I’m more likely to set a 330.
IMO a 330-size trap is a poor choice for otter unless it is fully submerged.
For fast moving otter’s a 330-size trap quite often closes on them to far back resulting in poor hip catches that don’t dispatch them quickly. My experience with the smaller 280 is that it closes faster and results in fewer, if any, poor catches. The 280 will also capture more of the incidental mink and muskrats that often trigger 330 beaver and otter sets without getting caught. Thus, it is the ultimate otter trap IMO.
I’m more likely to set a 330, because that’s what I have more of. Just like with dry land mink trapping, I prefer a larger trap, because I can and do add nearby vegetation to camouflage it, as well as narrow the trap opening when needed. I can use grass or sticks to reduce the size of the opening or not. It gives me the option of making a smaller trap out of a larger trap which is easier than making a larger trap out of a smaller trap.
Also, I use (2) trigger configurations for my 330s. Twisted together to make a T, dog down and twisted together as a single trigger wire, pushed to one side which helps me to catch beavers while avoiding
some otters and other smaller non targets. The T wires, set half submerged and blended as I prefer to set for otters, kills them stone dead.
If I were setting submerged BGs for otters, I would certainly agree with that a 280 is a better choice. I just prefer half submerged T triggers here. I know that’s not legal in a lot of states.