I doubt if you need to worry much bout drag using hundred pound test line,unless you just want to tire it out before landing.
This here is the whole point.
Musky are actually very fragile. We don't want to tire them out.
The longer the fight, and the warmer the water, the higher the mortality.
Into the net, the net stays in the water, cut the hooks (because they are usually wrapped in the net), pull out any embedded hook points, lift into boat for a quick measure, picture, and release.
Fish rests in the net in the water for a bit while getting the bump board out and camera ready, and then it's out of the water for maybe 45 seconds total.
I do back the drag off just a bit though. A really big fish isn't being perfectly controlled anyway and you need some give.
It might seem fanatical to try so hard to be gentle on them, but we really enjoy the challenge of the hunt, so we try our best.